Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AMPK activation. It also has anti-fibrotic activity, it reduces pulmonary fibrosis through Toll-Like receptor 4 pathways.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 18,000 | |||
5 mg | 在庫あり | ¥ 38,000 | |||
10 mg | 在庫あり | ¥ 65,000 | |||
25 mg | 在庫あり | ¥ 110,000 | |||
50 mg | 在庫あり | ¥ 158,000 | |||
100 mg | 在庫あり | ¥ 220,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 68,500 |
説明 | Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AMPK activation. It also has anti-fibrotic activity, it reduces pulmonary fibrosis through Toll-Like receptor 4 pathways. |
In vitro | MG IIIE elevated the cell viability of HG-induced MPC-5 cells, reduced the concentrations of inflammatory cytokines and decreased the levels of oxidative stress-related markers.?What's more, the apoptosis of podocytes induced by HG was inhibited after MG IIIE intervention, accompanied by the upregulated expression of Bcl-2 and downregulated expression of Bax, cleaved caspase-3 and cleaved caspase-9.?It was also found that MG IIIE could activate the AMPK/SIRT1 signaling, but compound C inhibited this pathway and reversed the inhibitory effects of MG IIIE on inflammation, oxidative stress and apoptosis in HG-stimulated podocytes. |
植物由来 |
分子量 | 963.15 |
分子式 | C48H82O19 |
CAS No. | 88901-37-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9.64 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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Mogroside III-E 88901-37-5 Apoptosis Immunology/Inflammation TNF IL Receptor TLR inhibit Inhibitor Mogroside IIIE Mogroside III E inhibitor