Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DPTN dihydrochloride is a potent and selective A3AR antagonist with Ki values of 1.65, 9.61 and 8.53 nM in human, mouse and rat, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 10,000 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 38,500 | |||
25 mg | 在庫あり | ¥ 84,000 | |||
50 mg | 在庫あり | ¥ 129,000 | |||
100 mg | 在庫あり | ¥ 181,500 | |||
500 mg | 在庫あり | ¥ 383,500 |
説明 | DPTN dihydrochloride is a potent and selective A3AR antagonist with Ki values of 1.65, 9.61 and 8.53 nM in human, mouse and rat, respectively. |
ターゲット&IC50 | A3 (human):1.65 nM (Ki) |
In vitro |
DPTN dihydrochloride is a potent antagonist of human, mouse, and rat A3AR. However, compared with human A3AR, DPTN dihydrochloride has a weaker effect and reduced selectivity in mice and rats (approximately 20 times that of A2BAR).[1] The binding affinity test of DNPT (10 μM) on the cell membrane of transfected HEK293 cells showed that its Ki values for hA1, hA2A, hA2B and hA3 were 162±49, 121±42, 230±40 and 1.65±0.57 nM respectively[ 1]. The Ki values of DPTN dihydrochloride at A1, A2A, A2B and A3 receptors are 411, 830, 189 and 9.61 nM (mouse); 333, 1147, 163 and 8.53 nM (rat) respectively.[1] |
分子量 | 459.39 |
分子式 | C22H20Cl2N4OS |
CAS No. | 325767-87-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.30 mg/mL (5 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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DPTN dihydrochloride 325767-87-1 GPCR/G Protein Neuroscience Adenosine Receptor DPTN Dihydrochloride DPTN DPTNdihydrochloride Inhibitor inhibitor inhibit