Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 36,500 | |||
5 mg | 在庫あり | ¥ 91,500 | |||
10 mg | 在庫あり | ¥ 136,000 | |||
25 mg | 在庫あり | ¥ 217,500 | |||
50 mg | 在庫あり | ¥ 294,000 | |||
100 mg | 在庫あり | ¥ 397,000 |
説明 | PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects. |
In vitro | In peripheral T cells, PSB-603 (100 nM) inhibits NECA-stimulated IL-6 release about 3-fold[2]. PSB-603 (10 μM) shows no affinity for the human and rat A1 and A2A and human A3 receptors[4]. |
In vivo | PSB-603 (5 mg/kg; i.p.) significantly reduces inflammation in local and systemic mice models of inflammation. In the inflamed paw, PSB-603 significantly decreases the levels of the inflammatory cytokines including IL-6, TNF-α and of ROS. PSB-603 reduces inflammation of the peritoneum by decreasing the infiltration of leukocytes[3]. |
別名 | PSB 603 |
分子量 | 529.01 |
分子式 | C24H25ClN6O4S |
CAS No. | 1092351-10-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 23.9mg/mL (45.1mM)
You can also refer to dose conversion for different animals. 詳細
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PSB-603 1092351-10-4 GPCR/G Protein Neuroscience Adenosine Receptor PSB603 PSB 603 Inhibitor inhibitor inhibit