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Emibetuzumab is a potent humanized bivalent MET antibody (IgG4 type). Emibetuzumab has antitumor activity, inhibition of HGF-dependent and independent MET pathway activation and tumor growth, and can be used to study advanced castration-resistant prostate cancer.
説明 | Emibetuzumab is a potent humanized bivalent MET antibody (IgG4 type). Emibetuzumab has antitumor activity, inhibition of HGF-dependent and independent MET pathway activation and tumor growth, and can be used to study advanced castration-resistant prostate cancer. |
In vitro | Emibetuzumab (LY2875358) inhibits HGF-stimulated proliferation of H596 at a concentration of 100 nmol/L for 6 days[1]. |
In vivo | Emibetuzumab (LY2875358) exhibits antitumor effects on MET-amplified xenograft mouse tumor models. It inhibits in vivo growth of glioblastoma U87MG xenograft tumors in mice at a dose of 10 mg/kg via intravenous administration once a week for 5 weeks. Additionally, a single intravenous dose of 10 or 20 mg/kg results in the downregulation of MET and pMET levels in the tumors of mice. The antitumor effects persist when administered once a week for 3, 5, or 6 weeks at a dose of 10 mg/kg[1]. |
別名 | LY2875358 |
分子量 | N/A |
CAS No. | 1365287-97-3 |
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You can also refer to dose conversion for different animals. 詳細
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Emibetuzumab 1365287-97-3 Tyrosine Kinase/Adaptors c-Met/HGFR LY 2875358 LY-2875358 LY2875358 Inhibitor inhibitor inhibit