Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fezolamine is a novel orally available non-tricyclic compound with antidepressant activity. It is three to two times more selective in blocking synaptosomal uptake of [3H]norepinephrine than uptake of [4H]3-hydroxytryptamine or [3H]dopamine in vitro. It blocked the inhibitory effects of rifampicin and tetraphenyl in classical behavioral tests using monoamine-depleted animals.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 26,000 | |||
5 mg | 在庫あり | ¥ 60,000 | |||
10 mg | 在庫あり | ¥ 89,500 | |||
25 mg | 在庫あり | ¥ 150,000 | |||
50 mg | 在庫あり | ¥ 213,000 | |||
100 mg | 在庫あり | ¥ 289,500 | |||
500 mg | 在庫あり | ¥ 581,000 |
説明 | Fezolamine is a novel orally available non-tricyclic compound with antidepressant activity. It is three to two times more selective in blocking synaptosomal uptake of [3H]norepinephrine than uptake of [4H]3-hydroxytryptamine or [3H]dopamine in vitro. It blocked the inhibitory effects of rifampicin and tetraphenyl in classical behavioral tests using monoamine-depleted animals. |
In vivo | Fezolamine (100-450 mg/day; oral; 6 weeks; 42 patients) significant improvement relative to the patient's prestudy state was observed after 2 weeks in both patient and physician-rating scales. Fifty-five percent of patients improved their Hamilton Psychiatric Rating Scale for Depression (HAM-D) scores by more than 50%. The median dose associated with a clinically significant response was 245 mg/day. Five of the 6 patients who dropped out did so because of gastrointestinal adverse effects. The most common adverse effects were nausea (36%), headache (29%), constipation (26%), and dry mouth (24%).[1] |
分子量 | 305.42 |
分子式 | C20H23N3 |
CAS No. | 80410-36-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (180.08 mM)
You can also refer to dose conversion for different animals. 詳細
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Fezolamine 80410-36-2 Neuroscience Norepinephrine Inhibitor inhibitor inhibit