Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Maprotiline hydrochloride (Psymion) is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
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50 mg | 在庫あり | ¥ 9,000 | |||
100 mg | 在庫あり | ¥ 12,500 | |||
200 mg | 在庫あり | ¥ 17,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Maprotiline hydrochloride (Psymion) is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use. |
In vitro | Maprotiline inhibits HERG channels expressed in HEK cells with an IC50 of 5.2 μM and HERG channels expressed in oocytes with an IC50 of 24 μM. Maprotiline blocks open channels but has no significant effect on closed channels. [1] Maprotiline is atetracyclic antidepressant, which strongly inhibits the uptake of noradrenaline, though it is notable in its lack of inhibition of serotonergic uptake. Maprotiline also has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. [2] Maprotiline decreases cell viability in a concentration- and time-dependent manner in Neuro-2a cells. Maprotiline induces apoptosis and increases caspase-3 activation. Maprotiline also induces [Ca(2+)](i) increases which involves the mobilization of intracellular Ca(2+) stored in the endoplasmic reticulum. [3] |
In vivo | Maprotiline results in significantly increases GluR1 and GluR2/3 subunit expression in the nucleus accumbens and dorsal striatum of mice as detected by immunohistochemistry; and significantly increases GluR1 and GluR2/3 expression in the hippocampus, as demonstrated by Western blot analysis. [4] Maprotiline has a potent anti-inflammatory effect in rats and this effect is linked to the peripheral and supraspinal actions of the drug. [5] Maprotiline impairs learning when administered before training, but no statistically significant effect is evident when administered after training. [6] |
別名 | Maprotiline HCl, Psymion, Deprilept, Ludiomil |
分子量 | 313.864 |
分子式 | C20H24ClN |
CAS No. | 10347-81-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 23 mg/mL (73.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 59 mg/mL (188 mM)
You can also refer to dose conversion for different animals. 詳細
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Maprotiline hydrochloride 10347-81-6 Autophagy GPCR/G Protein Immunology/Inflammation Neuroscience 5-HT Receptor Adrenergic Receptor Norepinephrine AChR Histamine Receptor Maprotiline Inhibitor Maprotiline Hydrochloride Maprotiline HCl inhibit Psymion Deprilept Ludiomil inhibitor