Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.
説明 | GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant. |
ターゲット&IC50 | GWL (human):4.9 µM, GWL-KinDom (human):4.9 µM |
In vitro | GKI-1 (25 and 50 µM, 0-8.5 h) reduces ENSA/ARPP19 phosphorylation levels in Hela cells, resulting in a decrease in mitotic events, mitotic arrest/cell death, and cytokinesis failure.[1] |
別名 | GKI-1 HCl( 2444764-03-6 Free base) |
分子量 | 306.19 |
分子式 | C15H13Cl2N3 |
CAS No. | T11402L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (146.97 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GKI-1 HCl T11402L Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells ROCK 2444764-03-6 Free base 2444764-03-6 GKI-1 HCl( 2444764-03-6 Free base) Inhibitor inhibitor inhibit