Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 inhibits human and mouse IRAK4 and could be used to study psoriasis and atopic dermatitis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 26,000 | |||
5 mg | 在庫あり | ¥ 64,000 | |||
10 mg | 在庫あり | ¥ 104,500 | |||
25 mg | 在庫あり | ¥ 203,500 | |||
50 mg | 在庫あり | ¥ 333,000 | |||
100 mg | 在庫あり | ¥ 532,500 |
説明 | GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 inhibits human and mouse IRAK4 and could be used to study psoriasis and atopic dermatitis. |
ターゲット&IC50 | IL-1β:55 nM, IRAK1:179 nM, mIRAK4:3.5 nM, hIRAK4:6.4 nM |
In vitro | GLPG2534 inhibits IL-6 release driven by IL-1β with an IC50 of 55 nM[1]. It also inhibits TNF-α-driven IL-6 release, with an IC50 of 6.6 μM[1]. When applied at concentrations ranging from 0.1 to 10 μM for 16 hours, GLPG2534 inhibits the expression of S100A7, DEFB4A, CXCL8, and TNF in ciliated epithelial cells stimulated with ciliogenesis-promoting factors[1]. |
In vivo | GLPG2534, administered orally at doses ranging from 0.3 to 10 mg/kg, inhibits CL097-driven TNF-α release in mouse blood[1]. Furthermore, oral administration of GLPG2534 at doses of 10 and 30 mg/kg, twice daily, alleviates inflammation in a psoriasis-like mouse model[1]. Additionally, GLPG2534, at doses of 3-30 mg/kg, orally administered twice daily for 5 days, mitigates the development of IL-33 and MC903-induced atopic dermatitis-like skin inflammation in mice[1]. |
別名 | GLPG-2534 |
分子量 | 424.45 |
分子式 | C21H24N6O4 |
CAS No. | 2095615-97-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (188.48 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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GLPG2534 2095615-97-5 Immunology/Inflammation NF-Κb IRAK GLPG-2534 Inhibitor inhibitor inhibit