Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS).
説明 | IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS). |
ターゲット&IC50 | IRAK4:3.55 nM |
In vitro | Compound BAY-1834845 (IRAK4-IN-20) at a concentration of 500 nM, effectively reduces the secretion of inflammatory cytokines when administered for 20 hours in an in vitro assay involving LPS-stimulated human peripheral blood mononuclear cells (PBMC) [1]. |
In vivo | IRAK4-IN-20 (Compound BAY-1834845), administered orally at a dosage of 150 mg/kg either once 30 minutes before or twice at 4 and 12 hours after LPS induction, significantly mitigated acute respiratory distress syndrome in female Balb/c mice models aged 6–7 weeks. This intervention markedly reduced the infiltration of inflammatory cells and neutrophil count in bronchoalveolar lavage fluid (BALF), decreased the numbers of total T cells, monocytes, and macrophages, and preserved the integrity of naïve lymphocytes and stromal cell populations, including endothelial cells, chondrocytes, and smooth muscle cells. Moreover, it more effectively regulated inflammation and innate immunity genes in comparison to Dexamethasone, underscoring its potential as a therapeutic agent for ARDS. |
別名 | BAY-1834845 |
分子量 | 450.45 |
分子式 | C22H25F3N4O3 |
CAS No. | 1931994-80-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (55.5 mM)
You can also refer to dose conversion for different animals. 詳細
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IRAK4-IN-20 1931994-80-7 Immunology/Inflammation NF-Κb IRAK BAY 1834845 BAY-1834845 BAY1834845 Inhibitor inhibitor inhibit