Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 15,000 | |||
5 mg | 在庫あり | ¥ 35,500 | |||
10 mg | 在庫あり | ¥ 55,000 | |||
25 mg | 在庫あり | ¥ 112,000 | |||
50 mg | 在庫あり | ¥ 163,500 | |||
100 mg | 在庫あり | ¥ 226,500 | |||
500 mg | 在庫あり | ¥ 454,500 |
説明 | IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. |
ターゲット&IC50 | IRAK4:7 nM. |
In vitro | The in vitro metabolic stability profiles of IRAK4-IN-1 is measured, with EC50 of 2300 nM for the rat whole blood (RWB) |
In vivo | Oral pharmacokinetic analyses of IRAK4-IN-1 indicate that it possesses a high bioavailability of 73%, along with low plasma clearance (Clp=22 mL/min/kg), which culminates in a stable half-life of 1.3 hours. |
動物実験 | In the TLR driven in vivo model, female Lewis rats are dosed with either vehicle or IRAK4-IN-1 (Compound 23; 3, 10, 30, and 100 mg/kg; p.o.) dosed at 1 h prior to stimulation with Resiquimod, R848 (5 mg/kg, IP). At 1.5 h post R848 stimulation, blood samples are obtained from the animals and cytokine levels are measured. |
分子量 | 337.42 |
分子式 | C19H23N5O |
CAS No. | 1820787-94-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 14.29 mg/mL (42.35 mM), Sonication is recommended.
H2O: < 0.1 mg/mL (insoluble)
You can also refer to dose conversion for different animals. 詳細
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IRAK4-IN-1 1820787-94-7 Immunology/Inflammation NF-Κb IRAK inhibit IRAK4 IN 1 Inhibitor IL-1R associated kinase Interleukin-1 receptor associated kinase IRAK4IN1 IRAK-4-IN-1 inhibitor