store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 has antitumor activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 15,500 | |||
5 mg | 在庫あり | ¥ 37,500 | |||
10 mg | 在庫あり | ¥ 66,500 | |||
25 mg | 在庫あり | ¥ 112,000 | |||
50 mg | 在庫あり | ¥ 160,000 | |||
100 mg | 在庫あり | ¥ 226,500 |
説明 | GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 has antitumor activity. |
ターゲット&IC50 | Chk1:0.0011 μM, Chk2:1.5 μM |
In vitro | GNE-900 (1 µM; 1-48 h; HT-29 cells) induces apoptosis and increases expression of cleaved PARP when combined with gemcitabine (50 nM) in HT-29 cells.[1] |
In vivo | GNE-900 (2.5-40 mg/kg; p.o.; once; Sprague-Dawley rats) combined with gemcitabine (120 mg/kg) reduced tumor volume and increased DNA damage and γ-H2AX expression levels in rats.[1] |
別名 | GNE900, GNE 900 |
分子量 | 367.45 |
分子式 | C23H21N5 |
CAS No. | 1200126-26-6 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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GNE-900 1200126-26-6 Apoptosis Cell Cycle/Checkpoint Chk GNE900 GNE 900 Omeprazole acid Inhibitor inhibitor inhibit