Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 15,500 | |||
5 mg | 在庫あり | ¥ 36,000 | |||
10 mg | 在庫あり | ¥ 57,500 | |||
25 mg | 在庫あり | ¥ 120,000 | |||
50 mg | 在庫あり | ¥ 174,500 | |||
100 mg | 在庫あり | ¥ 243,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 52,500 |
説明 | Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively. |
ターゲット&IC50 | PKCα:53 nM, PKCβ2:163 nM, PKCγ:213 nM, PKC:158 nM(Rat Brain), PKCβ1:195 nM, PKCε:175 nM |
In vitro | Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases. Bisindolylmaleimide VIII acetate (5 μM; 8, 12 hours) dramatically increases TRA-8-induced cell death in time-dependent and TRA-8 dose-dependent manners. Bisindolylmaleimide VIII acetate (5 μM; 6 hours) significantly decreases procaspase-8 at 4 h and completely disappears at 6 h after the combined treatment with TRA-8 [2]. |
In vivo | Bisindolylmaleimide VIII acetate (100 μg; i.p.; every other day for three doses) results in nearly complete tumor regression combined toTRA-8. The alone treatment with Bisindolylmaleimide VIII acetate does not induce significant tumor regression [2]. |
別名 | Ro 31-7549 acetate, Bis VIII acetate |
分子量 | 458.51 |
分子式 | C26H26N4O4 |
CAS No. | 138516-31-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (119.95 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Bisindolylmaleimide VIII acetate 138516-31-1 Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling PKC protein Ro 31-7549 acetate Ro 31-7549 Inhibitor Bis VIII acetate inhibit Ro 31-7549 Acetate Fas Bis VIII autoimmune Protein kinase C diseases kinase cell-mediated Bisindolylmaleimide VIII Bisindolylmaleimide VIII Acetate Bis VIII Acetate inhibitor