Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective against 6-OHDA.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 8,000 | |||
5 mg | 在庫あり | ¥ 18,500 | |||
10 mg | 在庫あり | ¥ 32,000 | |||
25 mg | 在庫あり | ¥ 66,500 | |||
50 mg | 在庫あり | ¥ 104,500 | |||
100 mg | 在庫あり | ¥ 153,500 |
説明 | GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective against 6-OHDA. |
ターゲット&IC50 | GSK-3:3.01 μM |
In vitro |
GSK3-IN-3 (VP07) (25 μM; 24 h) induces mitophagy in Parkin-expressing U2OS-iMLS cells, but with limited potency.[1] GSK3-IN-3 (1.56-25 μM; 24 h) causes mitochondrial fission and mitochondrial morphological changes in U2OS-iMLS-Parkin cells.[1] GSK3-IN-3 (VP0.7) (5 μM, 10 μM) showed neuroprotective effects against 6-OHDA in an in vitro cellular model of Parkinson's disease in SH-SY5Y cells.[2] |
分子量 | 429.55 |
分子式 | C24H35N3O4 |
CAS No. | 331963-27-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.8 mg/mL (8.7 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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GSK3-IN-3 331963-27-0 Autophagy PI3K/Akt/mTOR signaling Stem Cells GSK-3 Mitophagy Inhibitor inhibitor inhibit