Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyclin B1.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 111,000 | |||
10 mg | 在庫あり | ¥ 159,000 | |||
25 mg | 在庫あり | ¥ 248,000 | |||
50 mg | 在庫あり | ¥ 342,000 | |||
100 mg | 在庫あり | ¥ 452,500 |
説明 | H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyclin B1. |
ターゲット&IC50 | LS-180:2.9 μM, A549 cells:14.8 μM, HepG2 cells:9.6 μM, MDA-MB-231 cells:20.5 μM, SGC-7901:12.1 μM |
In vitro |
H1k (72 h) exhibits anti-proliferative activity against LS-180, HepG-2, SGC-7901, A549, and MDA-MB-231 cells, with IC50 values of 2.9, 9.6, 12.1, 14.8, and 20.5 μM respectively [1].H1k (0-50 μM; 24 h) triggers significant G2-M arrest in MDA-MB-231 and SGC-7901 cells in a dose-dependent manner [1]. H1k (0-20 μM; 6 h; MDA-MB-231 cells) induces autophagy to exert its anti-proliferative activity, with lysosomes being its functional target [1]. |
分子量 | 390.48 |
分子式 | C27H22N2O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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H1k Cell Cycle/Checkpoint CDK Inhibitor inhibitor inhibit