Powder: -20°C for 3 years | In solvent: -80°C for 1 year
inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.
In vitro | inS3-54A18 selectively impedes STAT3's interaction with its inherent target sequences and diminishes the expression of genes downstream of STAT3. It significantly reduces the wound healing capacity in A549 and MDA-MB-231 cells to 64% and 76% at a concentration of 5μM, and further decreases healing to 47% and 39%, respectively, at 10μM. Notably, inS3-54A18 does not interfere with either the basal or IL-6-stimulated activation of STAT3, but specifically inhibits the expression of a STAT3 target gene, survivin. |
分子量 | 373.83 |
分子式 | C23H16ClNO2 |
CAS No. | 328998-53-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 150 mg/mL (401.25 mM)
You can also refer to dose conversion for different animals. 詳細
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inS3-54A18 328998-53-4 JAK/STAT signaling Stem Cells STAT Inhibitor inS-3-54A18 inS3 54A18 inS354A18 inhibit inhibitor