Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 24,000 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 72,000 | |||
100 mg | 在庫あり | ¥ 114,000 | |||
500 mg | 在庫あり | ¥ 248,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,000 |
説明 | L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells. |
ターゲット&IC50 | DNA ligase I:12 μM |
In vitro |
L82 (0-50 μM; 6 d) reduced the proliferation of a normal breast epithelial cell line MCF10A and the breast cancer cell lines MCF7, HeLa, and HCT116 in a concentration-dependent manner.[2] L82 (50 μM; 0-48 h) shows cytostatic activity due to activation of the G1/S checkpoint in MCF7 cells.[2] |
分子量 | 309.67 |
分子式 | C11H8ClN5O4 |
CAS No. | 329227-30-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30.0 mg/mL (96.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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L82 329227-30-7 DNA Damage/DNA Repair DNA Inhibitor inhibitor inhibit