Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 8,500 | |||
5 mg | 在庫あり | ¥ 13,500 | |||
10 mg | 在庫あり | ¥ 21,000 | |||
25 mg | 在庫あり | ¥ 45,000 | |||
50 mg | 在庫あり | ¥ 79,000 | |||
100 mg | 在庫あり | ¥ 110,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 13,500 |
説明 | L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM). |
ターゲット&IC50 | DNA ligase I:5 µM, DNA ligase III:9 µM, DNA ligase IV:5 µM |
In vitro | L189 inhibits DNA ligases I, III and IV in DNA joining assays with purified proteins and in cell extract assays of DNA replication, base excision repair and non-homologous end joinging. L189 markedly increases killing of HCT116 colon cancer cells and the other cancer cell lines by ionizing radiation. |
分子量 | 246.29 |
分子式 | C11H10N4OS |
CAS No. | 64232-83-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 1 mg/mL
H2O: Insoluble
DMSO: 50 mg/mL (203.01 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
L189 64232-83-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis DNA TMZ inhibit DNA Ligase IV cancer DNA Ligase I DNA Ligase III L-189 L 189 DNA ligase cell death Inhibitor cytotoxicity inhibitor