Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Losulazine is a peripheral sympathetic antihypertensive compound that can be taken orally. Losulazine causes relatively modest, transient depletion of dopamine and norepinephrine in brain regions protected by the blood-brain barrier.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 19,500 | |||
5 mg | 在庫あり | ¥ 48,500 | |||
10 mg | 在庫あり | ¥ 71,500 | |||
25 mg | 在庫あり | ¥ 134,500 | |||
50 mg | 在庫あり | ¥ 179,000 | |||
100 mg | 在庫あり | ¥ 250,500 | |||
500 mg | 在庫あり | ¥ 500,500 |
説明 | Losulazine is a peripheral sympathetic antihypertensive compound that can be taken orally. Losulazine causes relatively modest, transient depletion of dopamine and norepinephrine in brain regions protected by the blood-brain barrier. |
In vivo | Groups of six female Upjohn Sprague-Dawley rats were treated orally with 10 mg/kg/day of losulazine and/or 18.75 mg/kg/day of bromocriptine for 15 or 27 days. Six rats were treated with losulazine plus 6.25 mg/kg/day of bromocriptine for 16 days followed by losulazine alone for 11 days. Rats treated with losulazine only were depleted of hypothalamic catecholamines, were hyperprolactinemic, and had interrupted estrous cycles and attenuated vaginal mucosa. Treatment with bromocriptine, a dopamine receptor agonist, resulted in suppression of serum prolactin and normal estrous cycles. Rats reverted back to hyperprolactinemia and anestrus shortly after bromocriptine withdrawal. These results suggest that hyperprolactinemia mediated through hypothalamic dopamine depletion is the mechanism of anestrus in rats treated with losulazine.[1] |
分子量 | 558.55 |
分子式 | C27H22F4N4O3S |
CAS No. | 72141-57-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1mg/ml, Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Losulazine 72141-57-2 GPCR/G Protein Neuroscience Dopamine Receptor Norepinephrine Inhibitor inhibitor inhibit