Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dasotraline hydrochloride (SEP-225289 hydrochloride) (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 9,500 | |||
10 mg | 在庫あり | ¥ 15,500 | |||
25 mg | 在庫あり | ¥ 22,500 | |||
50 mg | 在庫あり | ¥ 34,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | Dasotraline hydrochloride (SEP-225289 hydrochloride) (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. |
ターゲット&IC50 | Norepinephrine:6nM, Dopamine:4nM, SERT:11 nM |
In vivo | Acute administration of dasotraline decreases the spontaneous firing rate of LC NE (norepinephrine), VTA DA (dopamine), and DR 5-HT (serotonin) neurons in a dose-dependent manner by activating α2, D2, and 5-HT1A autoreceptors, respectively. Primarily, dasotraline significantly reduces the firing rate of LC NE neurons, while moderately impacting VTA DA and DR 5-HT neuronal activity. Concurrently, SEP-225289, known as (dasotraline), demonstrates equal potency in inhibiting both 5-HT and NE transporters, effectively extending the time for a 50% recuperation of firing activity in dorsal hippocampus CA3 pyramidal neurons following the inhibition induced by the microiontophoretic application of 5-HT and NE. Moreover, the average occupancies of dopamine and serotonin transporters by SEP-225289 escalate with dose increments, showing transporter occupancies of approximately 33%±11% and 2%±13% for 8 mg, 44%±4% and 9%±10% for 12 mg, and 49%±7% and 14%±15% for 16 mg, for dopamine and serotonin transporters, respectively. |
別名 | SEP-225289 hydrochloride |
分子量 | 328.66 |
分子式 | C16H16Cl3N |
CAS No. | 675126-08-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31 mg/mL (94.32 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Dasotraline hydrochloride 675126-08-6 GPCR/G Protein Neuroscience Dopamine Receptor 5-HT Receptor Serotonin Transporter Norepinephrine Dasotraline Dopamine Transporter inhibit Dasotraline Hydrochloride Inhibitor SERT SEP-225289 SEP 225289 Hydrochloride SEP225289 Hydrochloride SLC6A4 SEP 225289 5-HTT DAT SEP225289 SLC6A3 SEP-225289 hydrochloride SEP-225289 Hydrochloride inhibitor