Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 27,500 | |||
10 mg | 在庫あり | ¥ 41,000 | |||
25 mg | 在庫あり | ¥ 69,000 | |||
50 mg | 在庫あり | ¥ 103,500 | |||
100 mg | 在庫あり | ¥ 152,500 | |||
500 mg | 在庫あり | ¥ 319,000 |
説明 | MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer. |
In vitro | MDL-800 increased SIRT6 deacetylase activity with an EC50 value of 11.0 ± 0.3 μM; MDL-800 (10-50 μM) induced dose-dependent deacetylation of histone H3 in 12 NSCLC cell lines. Treatment with MDL-800 dose dependently inhibited the proliferation of 12 NSCLC cell lines with IC50 values ranging from 21.5 to 34.5 μM. The antiproliferation effect of MDL-800 was significantly diminished by SIRT6 knockout. Treatment with MDL-800 induced remarkable cell cycle arrest at the G0/G1 phase in NSCLC HCC827 and PC9 cells. Furthermore, MDL-800 (25, 50 μM) enhanced the antiproliferation of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in osimertinib-resistant HCC827 and PC9 cells as well as in patient-derived primary tumor cells, and suppressed mitogen-activated protein kinase (MAPK) pathway.[1] |
In vivo | In HCC827 cell-derived xenograft nude mice, intraperitoneal administration of MDL-800 (80 mg · kg-1 · d-1, for 14 days) markedly suppressed the tumor growth, accompanied by enhanced SIRT6-dependent histone H3 deacetylation and decreased p-MEK and p-ERK in tumor tissues.[1] |
別名 | MDL 800, MDL800 |
分子量 | 626.3 |
分子式 | C21H16BrCl2FN2O6S2 |
CAS No. | 2275619-53-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.63 mg/mL (100 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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MDL-800 2275619-53-7 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin MDL 800 MDL800 Inhibitor inhibitor inhibit