Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
説明 | Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) |
ターゲット&IC50 | SIRT1:56μM, SIRT2:59 μM |
別名 | SIRT1/2 Inhibitor IV, NSC 112546 |
分子量 | 360.43 |
分子式 | C21H16N2O2S |
CAS No. | 14513-15-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (27.74 mM), Sonication is recommended.
Ethanol: 5 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Cambinol 14513-15-6 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Phospholipase Sirtuin NSC-112546 Inhibitor inhibit SIRT1/2 Inhibitor IV NSC 112546 NSC112546 inhibitor