Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MS8511 HCl is a selective and potent covalent inhibitor of G9a/GLP that acts by targeting cysteine residues in the substrate binding site. MS8511 has anticancer activity and antiproliferative activity and reduces intracellular H3K9me2 levels.MS8511 can be used to study a wide range of cancers including brain, breast, and ovarian cancers .
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 111,000 | |||
10 mg | 在庫あり | ¥ 159,000 | |||
25 mg | 在庫あり | ¥ 248,000 | |||
50 mg | 在庫あり | ¥ 342,000 | |||
100 mg | 在庫あり | ¥ 452,500 |
説明 | MS8511 HCl is a selective and potent covalent inhibitor of G9a/GLP that acts by targeting cysteine residues in the substrate binding site. MS8511 has anticancer activity and antiproliferative activity and reduces intracellular H3K9me2 levels.MS8511 can be used to study a wide range of cancers including brain, breast, and ovarian cancers . |
ターゲット&IC50 | GLP:140 nM, G9a:44 nM (Kd), GLP:46 nM (Kd), G9a:100 nM |
In vitro |
MS8511 HCl (Compound 8), within a range of 0-100 μM over 10 minutes, selectively inhibits G9a and GLP compared to other PKMTs and PRMTs, with IC50 values of 100 nM (G9a) and 140 nM (GLP) [1].With a duration of 50 minutes, MS8511 HCl exhibits a preference for covalent modification of G9a over GLP, with Kd values of 44 nM (G9a) and 46 nM (GLP) [1].Over a range of 0-5 μM and durations of 24-72 hours,MS8511 HCl effectively reduces the H3K9me2 mark in MDA-MB-231 and K562 cells [1]. At concentrations ranging from 0.8 to 25 μM over a period of 3 days, MS8511 HCl inhibits the growth of MDA-MB-231 cells [1]. |
別名 | MS8511 HCl(2866408-21-9 Free base) |
分子量 | 532.12 |
分子式 | C28H42ClN5O3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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MS8511 HCl Chromatin/Epigenetic Histone Methyltransferase MS8511HCl(2866408219Freebase) MS8511 HCl(2866408-21-9 Free base) Inhibitor inhibitor inhibit