Powder: -20°C for 3 years | In solvent: -80°C for 1 year
mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer.
説明 | mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer. |
In vitro |
mTOR inhibitor-8 (Compound 5e; 0.1-10 μM) suppresses the growth of A549 cells in a dose-dependent manner after 24 and 48 hours of treatment[1]. mTOR inhibitor-8 induces autophagy in an mTOR-dependent manner. At a concentration of 10 μM, mTOR inhibitor-8 induces autophagy in a time-dependent manner (3-24 hours), leading to enhanced levels of LC3B-II[1].At a concentration of 10 μM for 3-24 hours, mTOR inhibitor-8 reduces the phosphorylation of RPS6KB1 (ribosomal protein S6 kinase) and EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1), two essential substrates of mTOR[1]. |
In vivo | In vivo, mTOR inhibitor-8 effectively inhibits tumor growth at concentrations of 25 and 50 μM for a duration of 6 days, without adversely affecting angiogenesis in the normal chick chorioallantoic membrane [1]. |
別名 | mTOR-IN-8 |
分子量 | 446.95 |
分子式 | C24H19ClN4OS |
CAS No. | 2489196-70-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (44.75 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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mTOR inhibitor-8 2489196-70-3 Autophagy PI3K/Akt/mTOR signaling mTOR mTOR inhibitor 8 mTOR inhibitor8 mTOR-IN-8 Inhibitor inhibitor inhibit