Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NCGC00092410 (ML008) is a glucocerebrosidase (GC) inhibitor with IC50 value of 31 nM. It can be used for the study of Gaucher disease caused by mutation of glucocerebrase gene.
説明 | NCGC00092410 (ML008) is a glucocerebrosidase (GC) inhibitor with IC50 value of 31 nM. It can be used for the study of Gaucher disease caused by mutation of glucocerebrase gene. |
ターゲット&IC50 | Glucocerebrosidase:31 nM |
In vitro | NCGC00092410 increased GC activity in N370S mutant fibroblasts. Treatment of Gaucher's fibroblasts with 40μM NCGC00092410 for 10-70 h increased the lysosomal content of GC in Gaucher's fibroblasts. NCGC00092410 inhibited GC activity with different substrate concentrations in a dose-dependent manner. [1]. |
別名 | ML008 |
分子量 | 353.46 |
分子式 | C21H27N3O2 |
CAS No. | 442898-34-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 37.5 mg/mL (106.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NCGC00092410 442898-34-2 Metabolism Glucosidase ML 008 NCGC-00092410 NCGC 00092410 ML-008 ML008 Inhibitor inhibitor inhibit