Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 12,500 | |||
5 mg | 在庫あり | ¥ 29,500 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 104,500 | |||
50 mg | 在庫あり | ¥ 154,500 | |||
100 mg | 在庫あり | ¥ 219,500 |
説明 | NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor. |
In vitro | NLG802 showed moderate direct (IC50 5 μM) and time dependent (7-fold shift) inhibition of CYP3A4, weak inhibition to CYP2D6 (IC50 19 μM) and CYP2C19 (IC50 47 μM), no inhibition of CYP450 1A2, 2B6, 2C8 and 2C9 (IC50 > 50 μM) and no induction of CYP1A2, 2B6 or 3A4 in human hepatocytes. NLG802 showed moderate inhibition of P-gp transporter activity in MDR1-MDCKII cells (IC50 27 μM), does not inhibit the anion and cation transporters OATP1B1, OATP1B3, OAT1, OAT3, OCT1 and OCT2 in HEK293 cells expressing these transporters (IC50 > 50 μM) or the BRCP transporter in Caco-2 cells[1]. |
分子量 | 395.92 |
分子式 | C20H30ClN3O3 |
CAS No. | 2071683-99-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225 mg/mL (568.3 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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NLG802 2071683-99-1 Metabolism Indoleamine 2,3-Dioxygenase (IDO) NLG-802 NLG 802 Inhibitor inhibitor inhibit