Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NLRP3-IN-17 is a potent, selective, and orally active inhibitor of the NLRP3 inflammasome, demonstrating an IC50 of 7 nM. It effectively inhibits NLRP3-dependent IL-1β secretion in mice, making it a valuable compound for research into chronic inflammatory diseases [1].
説明 | NLRP3-IN-17 is a potent, selective, and orally active inhibitor of the NLRP3 inflammasome, demonstrating an IC50 of 7 nM. It effectively inhibits NLRP3-dependent IL-1β secretion in mice, making it a valuable compound for research into chronic inflammatory diseases [1]. |
ターゲット&IC50 | NLRP3 inflammasome:7 nM |
In vivo | NLRP3-IN-17 (compound 15) administered orally at 3 mg/kg demonstrated favorable pharmacokinetic (PK) data, with an area under the curve (AUC), half-life (t 1/2), and bioavailability (F%) of 4.2 μg.h/mL, 2.91 h, and 56%, respectively [1]. Furthermore, at a single oral dose of 10 mg/kg, NLRP3-IN-17 significantly inhibited the secretion of NLRP3-dependent IL-1β, reducing IL-1β levels by 44% in an acute in vivo LPS+ATP stimulation model in female C57BL/6 mice [1]. |
分子量 | 394.49 |
分子式 | C21H22N4O2S |
CAS No. | 2254432-75-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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NLRP3-IN-17 2254432-75-0 Immunology/Inflammation NOD-like Receptor (NLR) Inhibitor inhibitor inhibit