Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
50 mg | 在庫あり | ¥ 7,500 | |||
100 mg | 在庫あり | ¥ 11,000 | |||
200 mg | 在庫あり | ¥ 15,000 | |||
500 mg | 在庫あり | ¥ 22,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV. |
In vitro | In lean mice, Stavudine (500 mg/kg/day) reduces mitochondrial DNA in the liver and muscle, inducing ketoacidosis during fasting periods. In obese mice, Stavudine (500 mg/kg/day) depletes mtDNA in White Adipose Tissue (WAT). |
In vivo | Stavudine reduces lipid content and influences the expression of lipid metabolism markers, such as C/EBPα, peroxisome proliferator-activated receptor γ, adipocyte lipid-binding protein 2, fatty acid synthase, and acetyl-CoA carboxylase. In 3T3-F442A cells, Stavudine induces apoptosis and reduces both lipid content and viability in 3T3-L1 adipocytes. Furthermore, in peripheral blood mononuclear cells (PBMC), Stavudine inhibits the production of p24 antigen by HIV-1, with an effective dose range of 0.04 μM to 0.2 μM (ED50 = 0.04 μM-0.2 μM). |
別名 | d4T, Sanilvudine, BMY-27857, NSC 163661 |
分子量 | 224.21 |
分子式 | C10H12N2O4 |
CAS No. | 3056-17-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (223.01 mM)
H2O: 22.4 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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Stavudine 3056-17-5 Apoptosis Autophagy Cell Cycle/Checkpoint DNA Damage/DNA Repair Immunology/Inflammation Microbiology/Virology Proteases/Proteasome Nucleoside Antimetabolite/Analog Reverse Transcriptase HIV Protease NOD-like Receptor (NLR) BMY27857 nucleoside inflammasome NSC-163661 mtDNA inhibit HIV antiretroviral analogue d4T Inhibitor Human immunodeficiency virus Amyloid-β NSC163661 Sanilvudine BMY-27857 BMY 27857 NSC 163661 inhibitor