Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.
説明 | NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation. |
In vitro | NS3694 (10, 50, and 100 μM) specifically inhibits cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9. In MCF-casp3 cells, NS3694 (10-100 μM) inhibits dose-dependently caspase 9, 3, and 7 processing, DFF45/ICAD, and PARP cleavage, and DEVDase activity and inhibits TNF-induced effector caspase activation and apoptosis[1]. |
分子量 | 358.7 |
分子式 | C15H10ClF3N2O3 |
CAS No. | 426834-38-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (153.33 mM)
You can also refer to dose conversion for different animals. 詳細
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NS3694 426834-38-0 Apoptosis Inhibitor NS-3694 Apaf-1 inhibit caspase-9 NS 3694 apoptosome inhibitor cytochrome c inhibitor