Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 19,500 | |||
5 mg | 在庫あり | ¥ 45,500 | |||
10 mg | 在庫あり | ¥ 75,500 | |||
25 mg | 在庫あり | ¥ 128,000 | |||
50 mg | 在庫あり | ¥ 181,000 | |||
100 mg | 在庫あり | ¥ 257,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 52,000 |
説明 | Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells. |
ターゲット&IC50 | Proliferation:4 μM(A2780CP cells) |
In vitro | Millepachine (2-8 μM; 24 h) inhibits ATP-binding cassette transporter activity in A2780CP cells. Millepachine (2-8 μM; 24 or 48 h) induces significant G2/M arrest and apoptosis of cisplatin-sensitive A2780S and cisplatin-resistant A2780CP cells. The percentage of cells in the G2/M fraction increased from 15.99% in vehicle cells to 24.93%, 60.67%, and 77.31% at dose of 2, 4, and 8 μM in A2780S cells, respectively. Millepachine (2-8 μM; 24 h) decreases topoisomerase II levels in A2780S and A2780CP cells. Millepachine (1.25-20 μM; 48 h) remarkably inhibits the proliferation of cisplatin-resistant A2780CP cells with an IC50 of 4 μM[1]. |
In vivo | Millepachine (20 mg/kg; i.v.) reduced tumor volume and tumor weight with the inhibitory rate of 73.21% and 65.58% in A2780S and A2780CP xenograft models, respectively. Millepachine does not induce acquired drug resistance in an excised A2780S xenograft model[1]. |
分子量 | 350.41 |
分子式 | C22H22O4 |
CAS No. | 1393922-01-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (285.38 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Millepachine 1393922-01-4 Apoptosis Chinese Millettia bioactive chalcone medicine natural Inhibitor pachycarpa inhibit antitumor herbal Benth cancer inhibitor