Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that is a selective and potent semaphorin3A, phospholipase C (PLC), and FabI inhibitor, inhibiting semaphorin3A and FabI.Vinaxanthone exhibits antimicrobial activity, blocking intracellular fatty acid synthesis and inhibiting the growth of Staphylococcus aureus.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 147,000 |
5 mg | 在庫あり | ¥ 314,500 |
25 mg | 在庫あり | ¥ 512,000 |
50 mg | 在庫あり | ¥ 638,000 |
100 mg | 在庫あり | ¥ 849,500 |
説明 | Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that is a selective and potent semaphorin3A, phospholipase C (PLC), and FabI inhibitor, inhibiting semaphorin3A and FabI.Vinaxanthone exhibits antimicrobial activity, blocking intracellular fatty acid synthesis and inhibiting the growth of Staphylococcus aureus. |
ターゲット&IC50 | PA:9.3 μM (mouse colon 26 adenocarcinoma), PA:44 μM (NIH3T3 cell), PA:5.4 μM (Rat brain) |
In vitro | Vinaxanthone exhibits selective inhibitory activity against phospholipase C (PLC) in rat brain, mouse colon 26 adenocarcinoma, and mouse fibroblast NIH3T3 cells, with IC50 values of 5.4, 9.3, and 44 μM, respectively.At a concentration of 0.1 mg/mL for 24 hours, Vinaxanthone enhances peripheral nerve regeneration and induces limited neovascularization in the cornea[1].At a concentration of 0.5 μM for 20 minutes, Vinaxanthone may protect against Doxorubicin-induced apoptosis in foot cells[3].In the range of 0.1-1 μM for 24 hours, Vinaxanthone improves the changes in renal tubular cell characteristics induced by TGF-β1[2]. |
In vivo | Vinaxanthone (SM-345431), administered by subconjunctival injection at a concentration of 0.1 mg/mL every two days for 3 weeks, accelerates peripheral nerve regeneration and functional recovery in a mouse corneal transplantation model[1].Vinaxanthone (SEMA3A-I), given by intraperitoneal injection at a dose of 20 µg, protects against podocyte injury induced by Adriamycin in a mouse model through an anti-apoptotic mechanism[3]. |
別名 | SM-345431 |
分子量 | 576.42 |
分子式 | C28H16O14 |
CAS No. | 133293-89-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (138.79 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Vinaxanthone 133293-89-7 Metabolism Microbiology/Virology Antibacterial Phospholipase SM345431 SM-345431 SM 345431 Inhibitor inhibitor inhibit