Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PBRM1-BD2-IN-5 is a potent inhibitor of the PBRM1 Bromodomain, demonstrating dissociation constant (Kd) values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and boasts an inhibitory concentration 50 (IC50) value of 0.26 μM for PBRM1-BD2. This compound effectively diminishes the interaction between the full-length PBRM1 and acetylated histone peptide within the PBAF complex in cell lysates, which positions it as a promising candidate for anticancer research.
説明 | PBRM1-BD2-IN-5 is a potent inhibitor of the PBRM1 Bromodomain, demonstrating dissociation constant (Kd) values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and boasts an inhibitory concentration 50 (IC50) value of 0.26 μM for PBRM1-BD2. This compound effectively diminishes the interaction between the full-length PBRM1 and acetylated histone peptide within the PBAF complex in cell lysates, which positions it as a promising candidate for anticancer research. |
In vitro | PBRM1-BD2-IN-5 (compound 16) (0-10 μM; 5 days) inhibits PBRM1-expressed LNCaP cells, and reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptides[1]. |
分子量 | 272.73 |
分子式 | C15H13ClN2O |
CAS No. | 2819989-61-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (183.33 mM)
You can also refer to dose conversion for different animals. 詳細
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PBRM1-BD2-IN-5 2819989-61-0 Chromatin/Epigenetic Epigenetic Reader Domain PBRM1BD2IN5 Inhibitor inhibitor inhibit