Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD-1/PD-L1-IN-27 is a potent inhibitor of PD-1/PD-L1, exhibiting an IC50 of 134 nM and demonstrating antitumor effects with minimal T cell cytotoxicity. It activates CD8+ T cells and mitigates T cell exhaustion [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 349,000 |
50 mg | 約8-10 週間 | ¥ 454,500 |
100 mg | 約8-10 週間 | ¥ 574,000 |
説明 | PD-1/PD-L1-IN-27 is a potent inhibitor of PD-1/PD-L1, exhibiting an IC50 of 134 nM and demonstrating antitumor effects with minimal T cell cytotoxicity. It activates CD8+ T cells and mitigates T cell exhaustion [1]. |
In vitro | PD-1/PD-L1-IN-27 (compound MZ58) administered at concentrations of 2.5, 5, 10, and 50 µM for 48 hours demonstrates antitumor activity while maintaining low cytotoxicity towards T cells [1]. |
In vivo | PD-1/PD-L1-IN-27, administered intragastrically at dosages of 10 and 25 mg/kg, exhibits an antitumor effect [1]. |
分子量 | 673.75 |
分子式 | C44H35NO6 |
CAS No. | 2891831-47-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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PD-1/PD-L1-IN-27 2891831-47-1 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 Inhibitor inhibitor inhibit