Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.
説明 | BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers. |
ターゲット&IC50 | PD-1/PD-L1:7.2 μM |
In vitro | BMS-8 demonstrates a more stable binding affinity for one PD-L1 monomer compared to another, with its ability to induce PD-L1 dimerization further enhanced by non-polar interactions involving Ile54, Tyr56, Met115, Ala121, and Tyr123 on each monomer, in addition to the involvement of water-mediated bridges at ALys124[2]. |
分子量 | 494.42 |
分子式 | C27H28BrNO3 |
CAS No. | 1675201-90-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (121.35 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BMS-8 1675201-90-7 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 PPI inhibit BMS8 BMS 8 Inhibitor PD-L1 PD-1 inhibitor