Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligible affinity for other receptors, ion channels, and enzymes. Additionally, PD 144418 oxalate demonstrates potential antipsychotic activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 22,500 | |||
2 mg | 在庫あり | ¥ 33,000 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 85,000 | |||
25 mg | 在庫あり | ¥ 137,000 | |||
50 mg | 在庫あり | ¥ 198,500 | |||
100 mg | 在庫あり | ¥ 266,500 | |||
500 mg | 在庫あり | ¥ 535,000 |
説明 | PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligible affinity for other receptors, ion channels, and enzymes. Additionally, PD 144418 oxalate demonstrates potential antipsychotic activity. |
ターゲット&IC50 | σ2 receptor:1377 nM (Ki), σ1 receptor:0.08 nM (Ki) |
In vitro | In vitro, PD 144418 counteracts the increase in cyclic GMP (cGMP) triggered by N-methyl-D-aspartate (NMDA) in rat cerebellar slices, without altering basal levels. This implies a significant role for σ1 sites in controlling actions induced by glutamine. Furthermore, PD 144418 enhances the reduction of 5-hydroxytryptophan induced by Haloperidol within the mesolimbic region, although it does not independently affect 5-HT and dopamine (DA) synthesis [1]. |
In vivo | Treatment with PD 144418 (10 mg/kg; intraperitoneal injection; male CD-1 mice) effectively antagonized Mescaline-induced scratching without affecting spontaneous motor activity, displaying an ED 50 of 7.0 mg/kg (i.p.). This outcome was observed in a study where male CD-1 mice were administered a single intraperitoneal dose of 10 mg/kg, resulting in the inhibition of scratching behaviors induced by Mescaline. |
分子量 | 372.42 |
分子式 | C20H24N2O5 |
CAS No. | 1794760-28-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (26.85 mM)
You can also refer to dose conversion for different animals. 詳細
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PD 144418 oxalate 1794760-28-3 GPCR/G Protein Sigma receptor PD 144418 Oxalate PD-144418 Oxalate PD144418 Oxalate Inhibitor inhibitor inhibit