Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PI3K/mTOR Inhibitor-12, a potent and selective orally active inhibitor, exhibits IC50 values of 0.06 nM for PI3Kα and 3.12 nM for mTOR, indicating significant antitumor activity with reduced liver toxicity [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 383,500 |
50 mg | 約8-10 週間 | ¥ 500,500 |
100 mg | 約8-10 週間 | ¥ 643,000 |
説明 | PI3K/mTOR Inhibitor-12, a potent and selective orally active inhibitor, exhibits IC50 values of 0.06 nM for PI3Kα and 3.12 nM for mTOR, indicating significant antitumor activity with reduced liver toxicity [1]. |
ターゲット&IC50 | PI3Kα:0.06 nM, mTOR:3.12 nM |
In vitro | PI3K/mTOR Inhibitor-12 (compound 48; 72 h) demonstrates anticancer activity by achieving half-maximal inhibitory concentration (IC50) values of 0.07 μM for PC-3 cells, 0.09 μM for HT-29 cells, and 0.54 μM for both HCT116 and LOVO cells, with 0.68 μM for HUVEC cells [1]. Additionally, at concentrations ranging from 0.25 to 1 μM over 12 to 48 hours, this compound effectively suppresses PI3K and mTOR activation in HCT116 and HT-29 cells [1]. |
In vivo | PI3K/mTOR Inhibitor-12 (compound 48; 20 mg/kg; orally, daily for 14 days) demonstrated effectiveness in suppressing the growth of HCT116 tumor xenografts in female BALB/c nude mice [1]. Additionally, when administered to male SD rats at 1 and 5 mg/kg intravenously and orally, this inhibitor exhibited rapid plasma clearance (1428 mL/h/kg) with a brief half-life (T 1/2) of 2.33 hours, and an area under the curve (AUC 0-∞) of 1356 h·ng/mL [1]. |
分子量 | 611.62 |
分子式 | C27H27F2N9O4S |
CAS No. | 2891692-83-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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PI3K/mTOR Inhibitor-12 2891692-83-2 PI3K/Akt/mTOR signaling PI3K Inhibitor inhibitor inhibit