Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay.
説明 | Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. |
ターゲット&IC50 | Autophagy:40 nM, Autophagy:90 nM |
In vitro | Autophinib targets VPS34 but not other lipid kinases, mTOR and TBK1. Autophinib appears to be ATP-competitive, targets VPS34 in cell lysate and induces cellular phenotypes consistent with VPS34 inhibition. Autophinib inhibits the accumulation of autophagosomes under fed as well as starved conditions, but does not affect the number of autolysosomes. Thus it is not a late stage autophagy inhibitor but an inhibitor of autophagosome formation. |
細胞研究 | Cell lines: HeLa cellsConcentrations: 30 μMIncubation Time: 18 hMethod: |
分子量 | 346.73 |
分子式 | C14H11ClN6O3 |
CAS No. | 1644443-47-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 64 mg/mL (184.6 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Autophinib 1644443-47-9 Autophagy PI3K/Akt/mTOR signaling PI3K inhibit Phosphoinositide 3-kinase Inhibitor inhibitor