store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約5 days | ¥ 16,500 |
10 mg | 約5 days | ¥ 22,500 |
25 mg | 約5 days | ¥ 38,500 |
50 mg | 約5 days | ¥ 57,000 |
100 mg | 約5 days | ¥ 84,000 |
説明 | Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells. |
In vitro | Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors. Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation[3]. |
In vivo | In Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week), significant improvement in forelimb grip strength and all limbs grip strength is observed from 12 to 22 weeks of age. Rilmenidine also decreases levels of mutant huntingtin[2]. |
別名 | Rilmenidine (hemifumarate), S-3341 hemifumarate |
分子量 | 238.28 |
分子式 | C12H18O3 |
CAS No. | 207572-68-7 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 30 mg/mL (125.90 mM)
DMSO: 5 mg/mL (125.90 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Rilmenidine hemifumarate 207572-68-7 Apoptosis Neuroscience Imidazoline Receptor Rilmenidine (hemifumarate) S-3341 hemifumarate Rilmenidine Inhibitor inhibitor inhibit