Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor.RMC-0331 has potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 85,500 | |||
10 mg | 在庫あり | ¥ 152,500 | |||
25 mg | 在庫あり | ¥ 314,500 | |||
50 mg | 在庫あり | ¥ 486,500 | |||
100 mg | 在庫あり | ¥ 725,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 91,500 |
説明 | RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor.RMC-0331 has potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions. |
ターゲット&IC50 | GDP/GTP:71 nM |
In vitro | The IC50 of RMC-0331 is 71 nM, as determined by in vitro GDP/GTP exchange rate measurements[1]. |
In vivo | In the SHP2 mutation model, RMC-0331 exhibits single-agent anti-tumor activity when administered orally at doses ranging from 100 to 250 mg/kg once daily in immunocompetent mice[1]. |
別名 | RM-023 |
分子量 | 499.91 |
分子式 | C22H25ClF3N5O3 |
CAS No. | 2488788-52-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (200.04 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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RMC-0331 2488788-52-7 MAPK Raf RMC 0331 RMC0331 RM-023 Inhibitor inhibitor inhibit