Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively. Demonstrating anti-inflammatory and anti-cancer properties, it significantly diminishes body weight gain in diet-induced obese rats.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 8,000 | |||
25 mg | 在庫あり | ¥ 12,000 | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 7,500 |
説明 | Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively. Demonstrating anti-inflammatory and anti-cancer properties, it significantly diminishes body weight gain in diet-induced obese rats. |
ターゲット&IC50 | GAL3:49 μM (Kd), GAL1:24 μM (Kd) |
In vitro | Thiodigalactoside (TDG; 250 and 500 μM) demonstrates a dose-dependent decrease in fat accumulation, as evidenced by reductions in triglyceride (TG) content and Oil Red O (ORO) staining[1]. |
In vivo | Thiodigalactoside (TDG; 5 mg/kg; IP; once per week for 5 weeks) results in dramatic inhibition of HFD-induced body weight gain. Thiodigalactoside (5 mg/kg; oral; daily or weekly for 5 weeks) gave less reduction in body weight gain compare with i.p.[2]. |
分子量 | 358.36 |
分子式 | C12H22O10S |
CAS No. | 51555-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PBS (pH 7.2): 10 mg/mL
H2O: 90 mg/mL (251.1 mM), Sonication is recommended.
DMF: 1 mg/mL
DMSO: 20 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Thiodigalactoside 51555-87-4 Immunology/Inflammation Galectin Inhibitor inhibitor inhibit