Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TD139 is an inhaled galectin-3 inhibitor (Kd: 14 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 22,500 | |||
2 mg | 在庫あり | ¥ 37,500 | |||
5 mg | 在庫あり | ¥ 63,500 | |||
10 mg | 在庫あり | ¥ 103,000 | |||
25 mg | 在庫あり | ¥ 154,500 | |||
50 mg | 在庫あり | ¥ 220,000 | |||
100 mg | 在庫あり | ¥ 296,000 |
説明 | TD139 is an inhaled galectin-3 inhibitor (Kd: 14 nM). |
ターゲット&IC50 | GAL3:14 nM (Kd) |
In vitro | TD139 has a high affinity for galectin-3 with a Kd of 14 nM and 10 nM for galectin-1, but low affinity for galectins 2, 4N, 4C, 7, 8N, or 9N [1]. |
In vivo | In primary lung AECs TD139 reduces TGF-β1–induced β-catenin translocation to the nucleus, with most of the β-catenin remaining at the cell surface. TD139 blocks TGF-β1–induced β-catenin phosphorylation. A marked reduction in fibrosis and β-catenin activation accompanied by the decreased galectin-3 expression is observed in the lungs of WT mice treated with TD139 [1]. Pretreatment of WT C57BL/6 mice with TD139 leads to the attenuation of liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4(+) T cells, as well as an increase in the total number of IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activates macrophages and prevents the apoptosis of liver-infiltrating MNCs [2]. |
分子量 | 648.64 |
分子式 | C28H30F2N6O8S |
CAS No. | 1450824-22-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
Ethanol: 3 mg/mL
DMSO: 55 mg/mL (84.79 mM)
You can also refer to dose conversion for different animals. 詳細
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TD139 1450824-22-2 Immunology/Inflammation Galectin TD-139 TD 139 Inhibitor inhibitor inhibit