Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L, with IC50 values of 5.21, 4.51, 6.77, 1.42, and 6.13 nM, respectively. It demonstrates antitumor activity in BaF3-CD74-NTRK1 G595R and BaF3-CD74-NTRK1 G667C xenograft models and inhibits the proliferation of Ba/F3 cells expressing single mutants SF, GK, and xDFG, with an IC50 range of 1.43-47.56 nM [1].
説明 | TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L, with IC50 values of 5.21, 4.51, 6.77, 1.42, and 6.13 nM, respectively. It demonstrates antitumor activity in BaF3-CD74-NTRK1 G595R and BaF3-CD74-NTRK1 G667C xenograft models and inhibits the proliferation of Ba/F3 cells expressing single mutants SF, GK, and xDFG, with an IC50 range of 1.43-47.56 nM [1]. |
In vitro | TRK-IN-24 (Compound 10g) at concentrations ranging from 3.7 to 300 nM inhibits the phosphorylation of AKT, TRKA, PLCγ1, and ERK in Ba/F3 cells [1]. |
In vivo | TRK-IN-24 (compound 10g) administered at a dosage of 50 mg/kg over a period of 10-14 days induced tumor regression by 72% and 78% in murine xenograft models of BaF3-CD74-NTRK1 G595R and BaF3-CD74-NTRK1 G667C, respectively [1]. |
分子量 | 659.82 |
分子式 | C39H45N7O3 |
CAS No. | 2937544-01-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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TRK-IN-24 2937544-01-7 Tyrosine Kinase/Adaptors Trk receptor Inhibitor inhibitor inhibit