Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 16,500 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
50 mg | 在庫あり | ¥ 61,000 | |||
100 mg | お問い合わせ | ¥ 91,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 18,000 |
説明 | Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM). |
ターゲット&IC50 | Trk:2-20 nM |
In vivo | In vivo, Larotrectinib?(60 and 200 mg/kg) reduces tumor growth in a KM12 mouse xenograft model[1]. |
動物実験 | Mice were maintained under aseptic conditions.?The care and treatment of experimental animals was in accordance with institutional guidelines.?5 × 10^5 KM12 cells were injected subcutaneously into the dorsal flank area of the mice.?Tumor volume was monitored by direct measurement with calipers and calculated by the formula: length × (width^2)/2.?Following the establishment of tumor and when the tumor size was between 150–200 mm^2, mice were randomly selected to receive diluent, 60 mg/kg/dose or 200 mg/kg/dose of Larotrectinib(LOXO-101).?LOXO-101 was administered by oral gavage once daily for 14 days.?After the last dose, tissue and blood were collected at 3, 6 and 24 hours post-treatment[1]. |
別名 | LOXO-101, ARRY-470 |
分子量 | 428.44 |
分子式 | C21H22F2N6O2 |
CAS No. | 1223403-58-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.6 mg/mL (10.74 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Larotrectinib 1223403-58-4 Apoptosis Tyrosine Kinase/Adaptors Trk receptor Trk Receptor LOXO101 ARRY 470 ARRY470 LOXO-101 inhibit Inhibitor ARRY-470 Tropomyosin related kinase receptor LOXO 101 inhibitor