Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 13,000 | |||
5 mg | 在庫あり | ¥ 32,000 | |||
10 mg | 在庫あり | ¥ 51,000 | |||
25 mg | 在庫あり | ¥ 86,500 | |||
50 mg | 在庫あり | ¥ 128,500 | |||
100 mg | 在庫あり | ¥ 180,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 39,500 |
説明 | ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase |
ターゲット&IC50 | MerTK:1.0 nM (IC50), Axl:0.7 nM (IC50) |
In vitro | ONO-7475 sensitized AXL-overexpressing?EGFR-mutant NSCLC cells to the EGFR-TKIs osimertinib and dacomitinib. In addition, ONO-7475 suppressed the emergence and maintenance of EGFR-TKI-tolerant cells[2]. |
In vivo | Mice fed a diet containing ONO-7475 exhibited significantly longer survival and, interestingly, blocked leukemia cell infiltration in the liver. In summary, ONO-7475 effectively kills acute myeloid leukemia cells?in vitro?and?in vivo?by mechanisms that involve disruption of diverse survival and proliferation pathways[1]. |
細胞研究 | Cell Line:High AXL-expressing cell: PC-9,HCC4011,H1975, PC-9KGR cells. Low AXL-expressing cell: HCC827, HCC4006, and H3255 cells. Concentration:0.0001 μM; 0.001 μM; 0.01 μM; 0.1 μM; 1 μM. Incubation Time:72 hours[1]. |
分子量 | 562.57 |
分子式 | C32H26N4O6 |
CAS No. | 1646839-59-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (177.76 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ONO-7475 1646839-59-9 Tyrosine Kinase/Adaptors Trk receptor TAM Receptor lung tumor leukemia inhibit solid ONO7475 Trk Receptor tolerant cancer Mer Tropomyosin related kinase receptor NSCLC EGFR ONO 7475 Tyro3 advanced mutunt Inhibitor Axl TKI acute metastatic inhibitor