Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apoptotic enzyme glyceraldehyde phosphate dehydrogenase in PC-12 and neuroblastoma cells.
説明 | TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apoptotic enzyme glyceraldehyde phosphate dehydrogenase in PC-12 and neuroblastoma cells. |
In vivo | Chronic TV3279 (26 mg kg-1 for 21 days; rats) similarly inhibited ∼50% of striatal ChE activity but did not affect MAO activity or amine levels. Accordingly, chronic TV3279 abolished the ability of TCP to initiate L-dopa-induced hyperactivity. In contrast, chronic as well as acute treatments with TV3279 reduced spontaneous motor activity.[2] |
分子量 | 272.34 |
分子式 | C16H20N2O2 |
CAS No. | 209394-29-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.73 mg/mL (10.01 mM)
You can also refer to dose conversion for different animals. 詳細
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TV 3279 209394-29-6 Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling PKC BCL TV3279 TV-3279 Inhibitor inhibitor inhibit