Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VT104 is a potent YAP/TAZ inhibitor with oral activity that can be used in cancer research. VT104 prevents palmitylation of endogenous TEAD1 and TEAD3 proteins.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 58,500 | |||
10 mg | 在庫あり | ¥ 95,500 | |||
25 mg | 在庫あり | ¥ 154,500 | |||
50 mg | 在庫あり | ¥ 217,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 64,000 |
説明 | VT104 is a potent YAP/TAZ inhibitor with oral activity that can be used in cancer research. VT104 prevents palmitylation of endogenous TEAD1 and TEAD3 proteins. |
In vitro | VT104 is a pan-TEAD binder, with low nanomolar IC50 values in proliferation assays using YAP1/TEAD-dependent cell lines [1]. |
In vivo | VT104 also exhibits a favorable pharmacokinetics profile with exposure sufficient for daily dosing in mice. In the NCI-H226 xenograft efficacy model, VT-104 is highly active with a TGI = 102% at 3 mg/kg PO [1]. |
分子量 | 420.43 |
分子式 | C25H19F3N2O |
CAS No. | 2417718-25-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (71.35 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
VT104 2417718-25-1 Stem Cells YAP Inhibitor inhibitor inhibit