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阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
TP2160L1	YAP-TEAD-IN-1 acetate	YAP-TEAD-IN-1 acetate (1659305-78-8 Free base)	YAP
			YAP
T60218	YAP/TAZ inhibitor-2		YAP
	YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative and antitumor activity [1].		YAP
T77725	YAP-TEAD-IN-3	IAG933	YAP
	YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434). YAP-TEAD-IN-3 inhibits YAP reporter gene expression (IC50 = 0.048 μM) and NCI-H2052 cell proliferation (IC50 ...		YAP
T13364	YAP/TAZ inhibitor-1		ROCK
	YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).		ROCK
TP2160	YAP-TEAD-IN-1		Others
	YAP-TEAD-IN-1 is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM). It shows a higher binding affinity to TEAD1 (Kd: 15 nM) than YAP (50-171) (Kd: 40 nM).		Others
TP2160L	YAP-TEAD-IN-1 TFA		Others
	YAP-TEAD-IN-1 TFA is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM). It shows a higher binding affinity to TEAD1 (Kd: 15 nM) than YAP (50-171) (Kd: 40 nM).		Others
T72888	YAP-TEAD-IN-2		YAP
	YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50) value of 2.7 nM [1].		YAP
T8421	TED-347		YAP
	TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.		YAP
T9053	Lats-IN-1		Others , YAP
	Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.		Others , YAP
T22372	MYF-01-37	1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one	Others , YAP
	MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.		Others , YAP
T9954	K-975		Others
	K-975 is a highly selective, orally active TEAD inhibitor, effectively inhibiting protein-protein interactions between TEAD and YAP1/TAZ.		Others
T3112	Verteporfin	BPD-MA,CL 318952	Apoptosis , YAP , VDA , Autophagy
	Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions. Verteporfin is also a photosensitizer used in photodynamic therapy. Verteporfin also induces apoptosis and inhibits autophagy.		Apoptosis , YAP , VDA , Autophagy
T3050	ML-7 hydrochloride	ML-7 HCl	Serine/threonin kinase , Myosin , YAP , PKA , PKC
	ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and...		Serine/threonin kinase , Myosin , YAP , PKA , PKC
T1477	AICAR	NSC105823,AICA Riboside,Acadesine,AICAR (Acadesine)	Mitophagy , YAP , AMPK , Autophagy
	AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.		Mitophagy , YAP , AMPK , Autophagy
T2008	LY294002	LY 294002,NSC 697286,SF 1101	Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
	LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ...		Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
T7038	4-Methylayapin	4-METHYL-6,7-METHYLENEDIOXYCOUMARIN	Others
	4-Methylayapin is a useful organic compound for research related to life sciences. The catalog number is T7038 and the CAS number is 15071-04-2.		Others
T9566	PY-60		Annexin A , YAP
	PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional program in the adult animal capable of remodeling the epidermi...		Annexin A , YAP
T77729	MY-1076		Apoptosis , YAP
	MY-1076 is a potent YAP inhibitor with antigastric cancer activity.MY-1076 dose-dependently induced G2/M phase block, induced YAP degradation and apoptosis, and inhibited microtubule protein polymerization.MY-1076 inhibi...		Apoptosis , YAP
T62077	VT103	VT-103,VT 103	YAP
	VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting YAP/TAZ-TEAD-promoted gene transcriptionment, blocking TEA...		YAP
T67872	VT104		YAP
	VT104 is a potent YAP/TAZ inhibitor with oral activity that can be used in cancer research. VT104 prevents palmitylation of endogenous TEAD1 and TEAD3 proteins.		YAP
T60148	MSC-4106		YAP
	MSC-4106, an orally active and potent YAP/TAZ-TEAD inhibitor, disrupts TEAD1 and TEAD3 auto-palmitoylation and demonstrates significant efficacy in the NCI-H226 tumor xenograft model [1].		YAP
T60144	TDI-011536		Others
	TDI-011536, a potent Lats kinase inhibitor, disrupts Hippo-Yap signaling and promotes the proliferation of lesioned heart muscle cells. This compound is valuable for research in organ conservation and regeneration.		Others
T69760	TT-10	TAZ-K	YAP
	TT-10 (TAZ-K), an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity, has potential application in heart disease research, specifically for conditions characterized by loss o...		YAP
T14997	Conteltinib	SY-707,CT-707	FAK , PYK2 , ALK
	Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK, and Pyk2.Conteltinib exhibits significant inhibition of FAK, overcomes hypoxia-mediated sorafenib resistance in hepatocellular carci...		FAK , PYK2 , ALK
T60013	GA-017		Others
	GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell prolifer...		Others
T6108	Ki16425	Debio 0719	LPA Receptor , LPL Receptor
	Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.		LPA Receptor , LPL Receptor
T76004	Super-TDU TFA
	Super-TDU TFA, a specialized YAP antagonist, specifically inhibits the interaction between YAP and TEADs. This compound demonstrates tumor growth suppression in a gastric cancer mouse model [1].
T22434	Super-TDU		Others
	Super-TDU, an inhibitory peptide, targets YAP-TEADs interaction.		Others
T83951	TM2 TEAD inhibitor
	TM2 TEAD inhibitor, a robust and reversible inhibitor of the TEA domain transcription factor, presents dual inhibitory concentrations (IC50) of 38 nM for TEAD4 auto-palmitoylation and 156 nM for TEAD2 palmitoylation. It ...
T83938	TAT-PDHPS1
	TAT-PDHPS1 is a peptide inhibitor targeting Yes-associated protein (YAP) signaling, composed of the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. It operates by binding to protein phosphatase 2...
TP1569	Super-TDU (TFA) (1599441-71-0 free base)	Super-TDU (TFA)
	uper-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
T78558	GNE-7883

T81056	SWTX-143		YAP
	SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptional activity of the YAP/TAZ-TEAD complex and demonstrating anti...		YAP
TP1383	Super-TDU 1-31
	Super-TDU (1-31) is a peptide of Super-TDU, which is an inhibitor of YAP-TEADs, shows potent anti-tumor activity.
T76005	Super-TDU (1-31)
	Super-TDU (1-31), a peptide fragment of Super-TDU, acts as an inhibitor of the YAP-TEAD complex. Demonstrating potent anti-tumor activity, it effectively suppresses tumor growth in a gastric cancer mouse model [1] [2].
T76005L	Super-TDU (1-31) (TFA)
	Super-TDU (1-31) TFA, a peptide fragment of Super-TDU, acts as an inhibitor of the YAP-TEAD complex. Demonstrating potent anti-tumor activity, it effectively suppresses tumor growth in a gastric cancer mouse model [1] [2...
T82165	HTH-02-006		AMPK
	HTH-02-006, a NUAK2 inhibitor (IC50 = 126 nM), decreases phosphorylated MYPT1 levels in HuCCT-1 cells and inhibits YAP-driven cell proliferation, hepatomegaly, and tumorigenesis. Additionally, it possesses an antifibroti...		AMPK

Compounds

YAP-TEAD-IN-1 acetate

TP2160L1

Synonym: YAP-TEAD-IN-1 acetate (1659305-78-8 Free base)

Target: YAP

YAP/TAZ inhibitor-2

YAP/TAZ inhibitor-1

Target: Others, YAP

MYF-01-37

T22372

Synonym: 1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one

Target: Others, YAP

Synonym: BPD-MA,CL 318952

Target: Apoptosis, YAP, VDA, Autophagy

ML-7 hydrochloride

T3050

Synonym: ML-7 HCl

Target: Serine/threonin kinase, Myosin, YAP, PKA, PKC

AICAR

T1477

Synonym: NSC105823,AICA Riboside,Acadesine,AICAR (Acadesine)

Target: Mitophagy, YAP, AMPK, Autophagy

LY294002

T2008

Synonym: LY 294002,NSC 697286,SF 1101

Target: Apoptosis, DNA-PK, Casein Kinase, PI3K, Autophagy

4-Methylayapin

T7038

Synonym: 4-METHYL-6,7-METHYLENEDIOXYCOUMARIN

Target: Annexin A, YAP

MY-1076

T77729

Synonym:

Target: Apoptosis, YAP

VT103

T62077

Synonym: VT-103,VT 103

Synonym: SY-707,CT-707

Target: FAK, PYK2, ALK

Target: LPA Receptor, LPL Receptor

Super-TDU (TFA) (1599441-71-0 free base)

TP1569

Synonym: Super-TDU (TFA)

Super-TDU (1-31) (TFA)

カタログ番号	製品名	別名	ターゲット
TN1489	3'-Methoxyapiin	Graveobioside B,3'-Methoxy apiin,Chrysoeriol 7-apiosylglucoside	Others
	3'-Methoxyapiin (Graveobioside B) is a flavonoid from the herbs of Eminium spiculatum.		Others
TN2353	8-Hydroxyapigenin	Isoscutellarein	Antioxidant , Influenza Virus
	8-Hydroxyapigenin (Isoscutellarein) is a brassinaceous compound derived from the plant Scutellaria baicalensis with anti-inflammatory, antioxidant and anti-influenza virus activity.		Antioxidant , Influenza Virus
T79933	(−)-N-Hydroxyapiosporamide	NHAP	NF-κB
	(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo. It has potential applications in colorectal cancer (CRC) research [1...		NF-κB
TN1210	2-Hydroxy-1-Methoxyaporphine		P450
	2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.		P450
TN2907	3,6-Dimethoxyapigenin		Others
	3,6-Dimethoxyapigenin is a natural product of Dodonaea, Sapindaceae. The catalog number is TN2907 and the CAS number is 22697-65-0. 3,6-Dimethoxyapigenin can be used as a reference standard.		Others
T83410	2,3,5,6-Tetramethoxyaporphine
	2,3,5,6-Tetramethoxyaporphine, a benzyl isoquinoline alkaloid with antitussive properties, can be extracted from Glaucium flavum Cr. (Family Papaveraceae) [1] [2].
TN2422	6-hydroxyapigenin-6-O-β-D-glucoside-7-O-β-D-glucuronide		Others
	6-hydroxyapigenin-6-O-β-D-glucoside-7-O-β-D-glucuronide is a natural product from Carthamus tinctorius Linn.		Others
T14149	AICAR phosphate	AICA Riboside phosphate,Acadesine phosphate	Mitophagy , NOS , YAP , AMPK
	AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose and lipid metabolism, and inhibits the production of pro-in...		Mitophagy , NOS , YAP , AMPK
T1679	Thiostrepton	Thiactin,Bryamycin,Alaninamide	DNA/RNA Synthesis , Antibacterial , Antibiotic
	Thiostrepton (Alaninamide) is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in de...		DNA/RNA Synthesis , Antibacterial , Antibiotic
T3S1416	Decursin	Decursinol angelate,(+)-Decursin	Apoptosis , PKC
	1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 ...		Apoptosis , PKC

天然物製品

3'-Methoxyapiin

TN1489

Synonym: Graveobioside B,3'-Methoxy apiin,Chrysoeriol 7-apiosylglucoside

Target: Others

8-Hydroxyapigenin

TN2353

Synonym: Isoscutellarein

Target: Antioxidant, Influenza Virus

(−)-N-Hydroxyapiosporamide

T79933

Synonym: NHAP

Target: NF-κB

2-Hydroxy-1-Methoxyaporphine

TN1210

Synonym:

Target: P450

3,6-Dimethoxyapigenin

TN2907

Synonym:

Target: Others

2,3,5,6-Tetramethoxyaporphine

T83410

Synonym:

Target:

6-hydroxyapigenin-6-O-β-D-glucoside-7-O-β-D-glucuronide

Synonym: AICA Riboside phosphate,Acadesine phosphate

Target: Mitophagy, NOS, YAP, AMPK

Thiostrepton

T1679

Synonym: Thiactin,Bryamycin,Alaninamide

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Decursin

T3S1416

Synonym: Decursinol angelate,(+)-Decursin

Target: Apoptosis, PKC

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-00005	YAP1 Protein, Human, Recombinant (Isoform 9, His)	Human	P. pastoris (Yeast)
	YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9.
TMPY-06815	SYAP1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Synapse-associated protein 1 (SYAP1), also known as PRO3113 and BSTA, belongs to the synapse-associated BSD domain family, featuring three α-helices and two conserved tryptophan and phenylalanine residues located at the ...
TMPH-03764	YAP1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor su...
TMPY-02648	PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors ( Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediate...
TMPY-04398	MST1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The t...
TMPH-01689	PLD6 Protein, Human, Recombinant (His)	Human	E. coli
	Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the...