Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative and antitumor activity [1].
説明 | YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative and antitumor activity [1]. |
In vitro | YAP/TAZ inhibitor-2 (compound 5) (0-20000 nM; 24 h) has antiproliferative activity with an IC 50 value of 5.33 nM in NCI-H226 cells [1]. |
In vivo | YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) exhibits anti-tumor activity without significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model) [1]. |
分子量 | 390.33 |
分子式 | C19H14F4N4O |
CAS No. | 2762617-31-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (230.6 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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YAP/TAZ inhibitor-2 2762617-31-0 Stem Cells YAP YAP/TAZ inhibitor-2 YAP/TAZinhibitor2 Inhibitor inhibitor inhibit