Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 14,000 | |||
5 mg | 在庫あり | ¥ 34,000 | |||
10 mg | 在庫あり | ¥ 55,000 | |||
25 mg | 在庫あり | ¥ 110,000 | |||
50 mg | 在庫あり | ¥ 177,500 | |||
100 mg | 在庫あり | ¥ 241,000 |
説明 | YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models. |
ターゲット&IC50 | OX2R:0.028(EC50), OX1R:2.75 μM(EC50) |
In vivo |
YNT-185 (20-40 mg/kg; i.p.) enhances alertness in mice.[1]. In a dose-dependent manner, YNT-185 (300 nmol; i.c.v.) significantly extends wakefulness for a period of 3 hours, accompanied by a reduction in non-rapid eye movement (NREM) sleep duration, in wild-type mice but not in OXRDKO mice.[1] |
分子量 | 615.74 |
分子式 | C33H37N5O5S |
CAS No. | 1804978-81-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.0 mg/mL (90.0 mM)
H2O: Insoluble
You can also refer to dose conversion for different animals. 詳細
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YNT-185 1804978-81-1 GPCR/G Protein Neuroscience OX Receptor YNT 185 YNT185 Inhibitor inhibitor inhibit