Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL 02-096 induces degradation of Wee1 and accumulation of DNA damage in MOLT-4 cells in vitro, In vitro in MOLT-4 cells, ZNL 02-096 induced Wee1 degradation, accumulation of DNA damage, cell cycle arrest in G2/M phase and apoptosis.ZNL 02-096 showed anti-proliferative effects in 300 cancer cell lines.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 60,500 |
2 mg | 在庫あり | ¥ 90,000 |
5 mg | 在庫あり | ¥ 153,500 |
10 mg | 在庫あり | ¥ 205,000 |
25 mg | 在庫あり | ¥ 310,000 |
50 mg | 在庫あり | ¥ 418,000 |
100 mg | 在庫あり | ¥ 562,500 |
説明 | ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL 02-096 induces degradation of Wee1 and accumulation of DNA damage in MOLT-4 cells in vitro, In vitro in MOLT-4 cells, ZNL 02-096 induced Wee1 degradation, accumulation of DNA damage, cell cycle arrest in G2/M phase and apoptosis.ZNL 02-096 showed anti-proliferative effects in 300 cancer cell lines. |
In vitro |
ZNL 02-096 (1 nM-10 μM; 24, 48, and 72 h; OVCAR8, COV362, and Kuramochi cells) induces CRBN-dependent anti-proliferative effects and synergizes with Olaparib. ZNL 02-096 (6 h) degrades Wee1 in OVCAR8 cells, with maximal degradation observed at a 100 nM treatment.[1] ZNL 02-096 (100 nM; 24 h) induces DNA damage, apoptosis, and deregulation of the G2/M checkpoint.[1] |
別名 | Pomalidomide-C3-adavosertib |
分子量 | 799.88 |
分子式 | C42H45N11O6 |
CAS No. | 2414418-49-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (62.51 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ZNL 02-096 2414418-49-6 Apoptosis Cell Cycle/Checkpoint Wee1 Pomalidomide-C3-adavosertib Inhibitor inhibitor inhibit