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T11120 |
Duocarmycin TM
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DNA Alkylation
,
Antibiotic
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Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic. |
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T8897 |
2-Iodoacetamide
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Iodoacetamide |
Others
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Iodoacetamide, an alkylating agent, is commonly utilized for cysteine alkylation in proteomics sample preparation. |
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T8330 |
BIO-013077-01
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TGF-beta/Smad
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BIO-013077-01 is a potent TGFbeta family type I receptors antagonist. |
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T0923 |
Busulfan
|
Myleran,Sulphabutin,Busulphan |
Apoptosis
,
DNA Alkylator/Crosslinker
,
DNA Alkylation
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Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation... |
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T4580 |
4-Octyl itaconate
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Nrf2
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4-Octyl Itaconate is a cell-permeable derivative of Itaconate, an anti-inflammatory metabolite. 4-Octyl Itaconate activates Nrf2 via alkylation of KEAP1 and also inhibits phosphorylation of STING. 4-Octyl Itaconate is an... |
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T1488 |
Procarbazine hydrochloride
|
NSC-77213 HCl,Procarbazine HCl |
DNA Alkylator/Crosslinker
,
DNA/RNA Synthesis
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|
Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarba... |
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T31551 |
Mipicoledine
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DMCHOCPEN,DM-CHOC-PEN,DM CHOC PEN |
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DM-CHOC-PEN is a DNA alkylation agent that may be used to treat brain cancer. |
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T10973 |
DC41SMe
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|
Others
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DC41SMe is a DC1 derivative that is cytotoxic to Ramos, Namalwa and HL60 / s with IC50s ranging from 18-25 pM. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylation molecules, used fo... |
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T11118 |
Duocarmycin SA
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|
Others
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Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastom... |
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T83019 |
Antiproliferative agent-38
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|
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Antiproliferative Agent-38 (COM 18), a tetracyclic compound, features a reactive ring nitrogen (likely the quinoline moiety) that resists N-alkylation. Despite its classification, it neither exhibits anti-malarial proper... |
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T38710 |
JH295
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|
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JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alky... |
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T61061 |
JH295 hydrate
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|
|
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JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor that inhibits cellular Nek2 by Cys22 alkylation (IC50 = 770 nM). JH295 hydrate is not active against the mitotic kinases, Cdk1,... |
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T79665 |
RUNX-IN-2
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Apoptosis
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RUNX-IN-2 (Compound Conjugate 3) covalently attaches to RUNX-binding sequences, preventing RUNX proteins from associating with their targets, thereby inhibiting cancer cell proliferation and inducing p53-dependent apopto... |
